Medicinal Uses and Indications
Today, standardized extracts of grape seed may be used to treat a range of health problems related to free radical damage, including heart disease, diabetes, and cancer. Grape seed extract has also been shown to protect against bacterial infections, such as Staphylococcus aureus. Some studies, mostly in animals, support these uses.
Flavonoids found in red wine may help to protect the heart by lowering LDL ("bad") cholesterol. The so called "French paradox" is the belief that drinking wine protects people living in France from developing heart disease at the high rates seen in people living in the United States. So far, however, there is no clear evidence that taking grape seed extract helps reduce the risk of heart disease. Some researchers speculate that the alcohol in the wine, not the flavonoids, could be responsible for any healthful effects. Others think it could be the combination of alcohol and flavonoids.
Drinking alcohol to protect against heart disease is not advocated by the American Heart Association and other organizations because of the potential for addiction and other serious problems, such as car accidents and the increased risk of hypertension, liver disease, breast cancer, and weight gain. If you do drink red wine, you should have no more than 2 glasses (20 g ethanol) per day if you are a man, and no more than 1 glass per day if you are a woman.
Chronic venous insufficiency
In chronic venous insufficiency, blood pools in the legs, causing pain, swelling, fatigue, and visible veins. A number of high quality studies have shown that OPCs from grape seed can reduce symptoms.
Edema, swelling caused by surgery or an injury, seems to go away faster when people take grape seed extract. Edema is common after breast cancer surgery, and one double-blind, placebo-controlled study found that breast cancer patients who took 600 mg of grape seed extract daily after surgery for 6 months had less edema and pain than those who took placebo. Another study found that people who took grape seed extract after experiencing a sports injury had less swelling than those who took placebo.
There is not enough evidence to say whether taking grape seed extract can lower cholesterol, although preliminary studies show promising results. A study of 40 people with high cholesterol looked at whether taking grape seed extract, chromium, a combination of both, or placebo for 2 months would lower cholesterol. The combination of grape seed extract and chromium was more effective than either grape seed alone or placebo in lowering total and LDL cholesterol.
Another study looked at the effects of a proprietary grape seed extract on lipid peroxidation (the breakdown of fats in the blood) in a group of heavy smokers. In the study, 24 healthy male smokers (aged 50 years or older) took either placebo or 2 capsules (75 mg of a grape procyanidin extracts and soy phosphatidalcholine), twice daily for 4 weeks. LDL cholesterol levels were lower in those taking the grape seed supplement than those taking placebo.
High blood pressure
Theoretically, grape seed extract might help treat hypertension or high blood pressure. Antioxidants, like the ones found in grape seed, help protect blood vessels from damage. Damaged blood vessels can lead to higher blood pressure. In several animal studies, grape seed extract substantially reduced blood pressure. More research is needed to determine whether grape seed extract helps people with high blood pressure.
Studies have found that grape seed extracts may prevent the growth of breast, stomach, colon, prostate, and lung cancer cells in test tubes. However, there is no clear evidence whether it works in humans. Antioxidants, such as those found in grape seed extract, may help reduce the risk of developing cancer. Grape seed extract may also help prevent damage to human liver cells caused by chemotherapy medications. Talk to your doctor or pharmacist before combining antioxidants with any chemotherapy drugs to make sure they interact safely together, and that they do not interfere with effects of the chemotherapy medications.
Grape seed extract is sometimes suggested for the following, although evidence is slight:
- Alzheimer disease
- Diabetes (improving blood sugar control)
- Improving night vision
- Protecting collagen and elastin in skin (anti-aging)
- Treating hemorrhoids
- Protecting against oxidative rancidity and bacterial pathogens
The use of herbs is a time-honored approach to strengthening the body and treating disease. Herbs, however, contain components that can trigger side effects and interact with other herbs, supplements, or medications. For these reasons, you should take herbs with care, under the supervision of a health care provider qualified in the field of botanical medicine. Common side effects include nausea, itching, dizziness, stomach upset, diarrhea, headache, sore throat, cough, and rash.
Pregnant or breastfeeding women should not take grape seed supplements.
Grape seed extract can potentially affect medications broken down by the liver. Numerous medications are broken down by the liver, so check with your physician. Also, OPCs in grape seed extract may interact with the following:
Anticoagulants (blood thinners): Grape seed extract may act as a blood thinner, and could increase the risk of bleeding if taken with other blood thinners such as warfarin (Coumadin), clopidogrel (Plavix), or aspirin. If you are taking blood-thinning medications, or have bleeding disorders, ask your doctor before taking grape seed extract.
Phenacetin: Drinking grape juice may increase how quickly the body breaks down Phenacetin to get rid of it. This may decrease the effectiveness of the Phenacetin you are taking.
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