HyperthyroidismThyrotoxicosis; Overactive thyroid; Graves disease - hyperthyroidism; Thyroiditis - hyperthyroidism; Toxic goiter - hyperthyroidism; Thyroid nodules - hyperthyroidism; Thyroid hormone - hyperthyroidism
Hyperthyroidism is a condition in which the thyroid gland makes too much thyroid hormone. The condition is often called overactive thyroid.
Although the thyroid gland releases the hormones which govern growth and metabolism, the brain (the pituitary and the hypothalamus) manages the release and the balance of the amount of hormones circulated.
The thyroid gland is an important organ of the endocrine system. It is located at the front of the neck just above where your collarbones meet. The gland makes the hormones that control the way every cell in the body uses energy. This process is called metabolism.
The thyroid gland, a part of the endocrine (hormone) system, plays a major role in regulating the body's metabolism.
Many diseases and conditions can cause hyperthyroidism, including:
- Graves disease (most common cause of hyperthyroidism)
- Inflammation (thyroiditis) of the thyroid due to viral infections, some medicines, or after pregnancy (common)
- Taking too much thyroid hormone (common)
- Noncancerous growths of the thyroid gland or pituitary gland (rare)
- Some tumors of the testes or ovaries (rare)
- Getting medical imaging tests with contrast dye that has iodine (rare, and only if there is a problem with the thyroid)
- Eating too much of foods that contain iodine (very rare, and only if there is a problem with the thyroid)
Common symptoms include:
A goiter is a swelling in the neck due to an enlarged thyroid gland. The size may range from a single small nodule to a large neck lump. The swollen thyroid can put pressure on the windpipe and esophagus which can cause a cough, wheezing, breathing difficulties or swallowing difficulties. A goiter only needs to be treated if it is causing symptoms.
Other symptoms that can occur with this disease:
- Breast development in men
- Clammy skin
- Feeling faint when you raise your hands
- High blood pressure
- Itchy or irritated eyes
- Itchy skin
- Nausea and vomiting
- Protruding eyes (exophthalmos)
- Skin blushing or flushing
- Skin rash on the shins
- Weakness of the hips and shoulders
Endocrine glands release hormones (chemical messengers) into the bloodstream to be transported to various organs and tissues throughout the body. For instance, the pancreas secretes insulin, which allows the body to regulate levels of sugar in the blood. The thyroid gets instructions from the pituitary to secrete hormones which determine the rate of metabolism in the body (the more hormone in the bloodstream, the faster the chemical activity; the less hormone, the slower the activity).
Exams and Tests
The health care provider will do a physical exam. The exam may find the following:
- High systolic blood pressure (the first number in a blood pressure reading)
- Increased heart rate
- Enlarged thyroid gland
- Shaking of the hands
- Swelling or inflammation around the eyes
- Very strong reflexes
- Skin, hair, and nail changes
Blood tests are also ordered to measure your thyroid hormones TSH, T3, and T4.
You may also have blood tests to check:
Imaging tests of the thyroid may also be needed, including:
Treatment depends on the cause and severity of symptoms. Hyperthyroidism is usually treated with one or more of the following:
- Antithyroid medicines (propylthiouracil or methimazole) which reduce or block the effects of the extra thyroid hormone
- Radioactive iodine to destroy the thyroid gland and stop the excess production of hormones
- Surgery to remove the thyroid
If your thyroid is removed with surgery or destroyed with radioactive iodine, you must take thyroid hormone replacement pills for the rest of your life.
Medicines called beta-blockers may be prescribed to treat symptoms such as fast heart rate, tremor, sweating, and anxiety until the hyperthyroidism can be controlled.
Hyperthyroidism is treatable. Some causes may go away without treatment.
Hyperthyroidism caused by Graves disease usually gets worse over time. It has many complications, some of which are severe and affect quality of life.
Thyroid crisis (storm) is a sudden worsening of hyperthyroidism symptoms that may occur with infection or stress. Fever, decreased alertness, and abdominal pain may occur. People need to be treated in the hospital.
Other complications of hyperthyroidism include:
- Heart problems such as fast heart rate, abnormal heart rhythm, and heart failure
- Eye disease (double vision, ulcers of the cornea, vision loss)
Surgery-related complications, including:
- Scarring of the neck
- Hoarseness due to nerve damage to the voice box
- Low calcium level due to damage to the parathyroid glands (located near the thyroid gland)
- Hypothyroidism (underactive thyroid)
Tobacco use may make some complications of hyperthyroidism worse.
When to Contact a Medical Professional
Call your provider if you have symptoms of hyperthyroidism. Go to an emergency room or call 911 or the local emergency number if you have:
- Change in consciousness
- Rapid, irregular heartbeat
Call your provider if you are being treated for hyperthyroidism and you develop symptoms of underactive thyroid, including:
- Mental and physical sluggishness
- Weight gain
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